CHO Cell Line Development

Chinese Hamster Ovary (CHO) cells are used in the development and production of recombinant proteins.


TLA analyses can identify:


  • The genomic position(s) of transgene integration site(s).
  • Single nucleotide variants in the transgene sequence.
  • Structural changes in the transgene sequence and integration site.
  • Changes resulting from targeted (trans)gene editing.


The TLA technology can be utilised in various stages of CHO cell line development (e.g. early stage clone selection) or to assess the genetic stability and clonality of Master Cell Banks, Working Cell Banks and End-of-Production cells.


Cergentis supports many leading pharmaceutical companies in CHO cell development and Quality Control.



Watch a replay of a recent webinar on TLA-based targeted transgene & integration site sequencing in (CHO) cell line development and quality control.






  • "TLA analysis has proven to be very useful to quality control genetically engineered cell lines”


    Dr. John Wiseman - Associate Director (Molndal, Sweden)  

  • "TLA outperforms traditional methods used in CHO cell line characterisation and provides higher resolution and sensitivity.”


    Dr. Stefanie Bartels - Project Leader - Cell Line Development (The Netherlands)

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For Research Use Only.Not for use in diagnostic procedures.
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