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Transgenes & Integration Sites

TLA analyses with both the cell-based and genomic DNA protocols enable the sequencing of integration sites and integrated sequences in a wide variety of applications.

 

Applications include: 

 

  • Transgene & integration site sequencing in cell lines, animal models, and plants
  • HIV virus integration site sequencing in humans 
  • HBV virus integration site sequencing in tumours

 

TLA analyses identify:

 

  • The genomic position(s) of integration site(s)
  • Single nucleotide variants in the transgene sequence
  • Structural changes in the transgene sequence
  • Changes resulting from targeted (trans)gene editing

 

 

  • "TLA has proven to be a powerful technology for transgene integration site sequencing and for evaluation of structural changes in the transgene and/or integration site.”

    Ludwig Maximilians University Munich

    Dr. Nik Klymiuk - Molecular Animal Breeding and Biotechnology (Germany)

  •    "TLA is a highly efficient method for mapping the insertion site of any transgene.” 

                                                                         Genentech                                                                                        

    Dr. Søren Warming - Associate Director/Senior Scientist (San Francisco, CA, USA)

  • "Cergentis quickly determined transgene insertion for three out of three lines along with providing information on deletions and rearrangements in chromosomal DNA at the site. The service was quick, accurate and reasonably priced, and reports were complete and helpful.”

                                       Harvard University                                     

    Prof. Dr. Joshua Sanes - Department of Molecular and Cellular Biology (Cambridge, MA, USA)

  • "The main advantage of TLA over conventional approaches is that it generates complete sequence information of a region of interest."

                                                                            Taconic                                                                                                                                                                                           

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