Knowledge is increasing about which genetic alterations in which genes are relevant for therapy decisions in different subtypes of adult and paediatric leukaemia. 


TLA's unique ability to sequence complete genes and detect all single nucleotide variants and structural variants (including gene fusions) provides important advantages in the analysis and diagnosis of these genes. 


The TLA technology can be applied both in the analysis of individual genes of interest and in multiplex analyses. 


Examples of the application of multiplex and monoplex TLA analyses in various kinds of leukaemia are provided in the publications cited below. 




TLA technology & targeted complete NGS of genes and gene fusions in leukaemia





  • "Thank you so much. Data about the structural changes in our patient are very clear. Really powerful technology!”

    Alfredo Brusco Ph.D.(Department of Medical Sciences, University of Turin, Italy)
  • "Unknown translocation partners that drive expression of oncogenes as consequence of cryptic or previous unidentified chromosomal rearrangements were identified in T-cell leukemia patients using Targeted Locus Amplification.”

    Jules Meijerink Ph.D.(Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands)
  • "Targeted Locus Amplification enables fast identification of new chromosomal rearrangements and genomic breakpoint sequences in human T-ALL and unraveled a higher complexity of chromosomal translocations of known T-ALL oncogenes as thus far appreciated.”

    Pieter van Vlierberghe Ph.D.(Center for Medical Genetics, Ghent University, Belgium)
  • "We conclude that TLA is an effective method for the reliable detection of sequence mutations and structural variations that are relevant for disease prognosis in pediatric leukemia.”

    Roland Kuiper Ph.D.(Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands)
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For Research Use Only.Not for use in diagnostic procedures.
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