Knowledge is increasing about which genetic alterations in which genes are relevant for therapy decisions in different subtypes of adult and paediatric leukaemia. 


TLA's unique ability to sequence complete genes and detect all single nucleotide variants and structural variants (including gene fusions) provides important advantages in the analysis and diagnosis of these genes. 


The TLA technology can be applied both in the analysis of individual genes of interest and in multiplex analyses. 


Examples of the application of multiplex and monoplex TLA analyses in various kinds of leukaemia are provided in the publications cited below. 




TLA technology & targeted complete NGS of genes and gene fusions in leukaemia





  • "Unknown translocation partners that drive expression of oncogenes as consequence of cryptic or previous unidentified chromosomal rearrangements were identified in T-cell leukemia patients using Targeted Locus Amplification.”

    Princess Máxima Center for Pediatric Oncology

    Dr. Jules Meijerink - Principal Investigator (Utrecht, The Netherlands)

  • "We conclude that TLA is an effective method for the reliable detection of sequence mutations and structural variations that are relevant for disease prognosis in pediatric leukemia.”

                                  Princess Máxima Center for Pediatric Oncology                              

    Dr. Roland Kuiper - Senior PI (Utrecht, The Netherlands)

  • "Thank you so much. Data about the structural changes in our patient are very clear. Really powerful technology!”

                                                                  University of Turin                                                                    

    Prof. Dr. Alfredo Brusco - Department of Medical Sciences (Italy)

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