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  • Tuesday 2 October 2018

    New Glenmark paper: TLA and clonal derivation assessment of (CHO) cell lines

    In a recent paper published in the journal of Biotechnology, Glenmark Pharmaceuticals S.A. describes the use of the TLA technology in the analytical assessment of clonal derivation of cell populations.


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  • Monday 13 August 2018

    New Harvard paper on the importance of mapping transgene integration sites

    A new paper, published by the Sanes lab of Harvard University, again highlights the value and importance of mapping transgene integration site(s). 

     
    The paper, entitled "Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes And Neighboring Endogenous Genes”, illustrates the biological impact of the genomic position of transgene integration sites. 

    New Harvard paper on the importance of mapping transgene integration sites
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  • Thursday 12 July 2018

    TLA data used in study to determine genetic cause of belted cattle phenotype

    Recently, the University of Munich published a paper about the genetic background of the belted cattle phenotype.

     

    Their conclusions are that, partly based on data generated with the Targeted Locus Amplification technology, a quadruplication on bovine chromosome 3 was identified as the cause of the belted phenotype.

    TLA data used in study to determine genetic cause of belted cattle phenotype
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  • Tuesday 19 December 2017

    New JAX - Cergentis paper on mouse transgene integration site sequencing

    On December 18th, 2017, a new paper was published by The Jackson Laboratory (Bar Harbor, ME, USA) and Cergentis (Utrecht, The Netherlands) entitled: "Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis”.

    New JAX - Cergentis paper on mouse transgene integration site sequencing
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  • Friday 3 March 2017

    New Nature publication; MSKCC uses TLA to QC CRISPR-mediated genome editing

    On March 3rd, a new paper from the Memorial Sloan Kettering Cancer Center was published in Nature, entitled: Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. The comprehensive paper discusses the targeted CRISPR/Cas9-mediated integration of a CAR transgene into a specific locus. The Targeted Locus Amplification (TLA) technology has been used to sequence and map the AAV integrations.

    New Nature publication; MSKCC uses TLA to QC CRISPR-mediated genome editing
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  • Tuesday 10 January 2017

    New Genentech - Cergentis paper on mouse transgene integration site sequencing

    On January 3rd, 2017, Genentech (San Francisco, USA) and Cergentis (Utrecht, The Netherlands) published a paper entitled: "Efficient mapping of transgene integration sites and local structural changes in Cre transgenic mice using targeted locus amplification". The paper, published in Nucleic Acids Research, describes the TLA-based analysis of 7 widely used transgenic Cre mouse lines. The Targeted Locus Amplification (TLA) technology was used to map the integration sites of the transgenes.

    New Genentech - Cergentis paper on mouse transgene integration site sequencing
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