Additional Service Packages
CLONALITY ASSURANCE PACKAGE
TLA in combination with breakpoint-based qPCR for rapid, cost-effective clonality assurance of your master cell bank (MCB).
Starting at €25,000
Includes analysis of: MCB + control sample 4 primer sets with extended sequencing 93 subclones + 3 controls (96 samples total*) 2 breakpoint qPCR analyses per sample Deliverables: Extensive report describing Vector integrity (MCB sample) Integration site analysis (MCB) Results of evaluation of MCB specific breakpoints in 93 subclones Statistical calculation of probability of clonality of MCB
-> 10 week turnaround time
*subclone generation not included
GENETIC STABILITY PACKAGE
Complete genetic analysis of and documentation on the genetic make-up and genetic stability across various generations (e.g. MCB, WCB 3 generation times, EOP) characterizing your cell line at 5 different time points using TLA to gain genetic insight into consistent production of your biologics.
Starting at €20,000
Includes analysis of: 5 samples: MCB, WCB (3 generation times), EOP 4 primer sets with extended sequencing Deliverables: Extensive report describing Vector integrity (all samples) Integration site analysis (all samples) Comparison of all samples
-> 4 week turnaround time
Clonality assurance and genetic stability analysis: The full package.
Starting at €42,000
Includes: Clonality Assurance Package Genetic Stability Package
-> 14 week turnaround time
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