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Appnotes

Cergentis and its partners have published various application notes about the TLA technology, its applications and the automation of the TLA protocol. 

 

Please select an application to review the corresponding appnotes:

  • Automation
  • Application note: Automated TLA for Targeted Complete Transgene & Integration Sequencing in Pharmaceutical Cell Line Development & Quality Control
    Application note: Automated TLA for Targeted Complete Transgene & Integration Sequencing in Pharmaceutical Cell Line Development & Quality Control
  • Cell Line Development
  • Targeted Locus Amplification and NGS combined with qPCR-based breakpoint analysis for the assurance of monoclonality in recombinant cell lines
    Targeted Locus Amplification and NGS combined with qPCR-based breakpoint analysis for the assurance of monoclonality in recombinant cell lines
  • Application of Targeted Locus Amplification for Enhanced Apollo X CHO Clone Screening
    Application of Targeted Locus Amplification for Enhanced Apollo X CHO Clone Screening
  • Application note: Automated TLA for Targeted Complete Transgene & Integration Sequencing in Pharmaceutical Cell Line Development & Quality Control
    Application note: Automated TLA for Targeted Complete Transgene & Integration Sequencing in Pharmaceutical Cell Line Development & Quality Control
  • Application note on the use of the TLA technology in transgene and integration site sequencing in CHO cell lines.
    Application note on the use of the TLA technology in transgene and integration site sequencing in CHO cell lines.
  • Application note on Genedata Selector for Efficient and High Quality CHO Cell Line Development - Leveraging TLA for complete sequencing of expression constructs and integration sites
    Application note on Genedata Selector for Efficient and High Quality CHO Cell Line Development - Leveraging TLA for complete sequencing of expression constructs and integration sites
  • Cell and Gene Therapy
  • Application note on targeted complete NGS and QC of transgenes and integration sites in upstream cell and gene therapy manufacturing
    Application note on targeted complete NGS and QC of transgenes and integration sites in upstream cell and gene therapy manufacturing
  • Application note on targeted complete NGS and QC of transgenes, integration sites and gene editing in heterogeneous cell and gene therapy products
    Application note on targeted complete NGS and QC of transgenes, integration sites and gene editing in heterogeneous cell and gene therapy products
  • Clinical Genetics
  • Poster: TLA & Long Read Sequencing: Efficient Targeted Sequencing and Phasing of the CFTR Gene
    Poster: TLA & Long Read Sequencing: Efficient Targeted Sequencing and Phasing of the CFTR Gene
  • Application Note Pacific Biosciences - Targeted Sequencing and Chromosomal Haplotype Assembly Using Cergentis TLA Technology with PacBio SMRT Sequencing.
    Application Note Pacific Biosciences - Targeted Sequencing and Chromosomal Haplotype Assembly Using Cergentis TLA Technology with PacBio SMRT Sequencing.
  • Application note on the TLA protocol for isolated genomic DNA.
    Application note on the TLA protocol for isolated genomic DNA.
  • Genome Editing
  • Appnote: TLA for complete locus sequencing and quality control of targeted genome editing
    Appnote: TLA for complete locus sequencing and quality control of targeted genome editing
  • Leukaemia
  • Application note on the application of TLA in gene fusion detection in pediatric leukaemia
    Application note on the application of TLA in gene fusion detection in pediatric leukaemia
  • Application note on MRD testing using TLA data
    Application note on MRD testing using TLA data
  • Solid Tumours
  • Robust detection of structural variants and single nucleotide variants in FFPE
    Robust detection of structural variants and single nucleotide variants in FFPE
  • Transgenic Models
  • Application note on TLA-based transgene and -integration site sequencing.
    Application note on TLA-based transgene and -integration site sequencing.

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For Research Use Only.Not for use in diagnostic procedures.