Advanced genetic characterization of your genetically engineered models
Random transgenesis, resulting from pronuclear injection to generate transgenic strains, can potentially disrupt key endogenous genes. As such, identifying the exact genomic position(s) of a transgene insertion site will allow better genotype-phenotype correlation, enhance predictability of transgene segregation during breeding and intercrossing or even facilitate the determination of zygosity via genotyping. Similarly, genome editing tools such as CRISPR-Cas9 can result in undesired on-target sequence variants ranging from single base pair variants up to large structural rearrangements. Therefore, comprehensive sequence analysis of targeted loci is critical for the selection and QC of genetically modified cells and organisms.
In this webinar, we discuss:
- Genetic characterization challenges for modified organisms and transgenic animals
- Conventional technologies and how they can be suboptimal when it comes to fully addressing those genetic QC needs
- How we routinely alleviate these genetic QC pains for our customers, by generating meaningful data on their samples and complex projects with our TLA-based solutions.
With almost a decade of experience, our unbiased and robust genetic QC testing method has been featured in over 70 peer-reviewed publications by both leading pharma/biotech (e.g. Genentech) as well as renowned academic research institutions (e.g. The Jackson Laboratory, Harvard University) globally. As such, our PhD-level experts have substantial experience analyzing a wide variety of modified organisms.
For an overview of the publications cited in the presentation, click here
Please contact us for more information.